ʻO Florfenicol kahi lāʻau lapaʻau ākea-no ka papa amide. He lāʻau bacteriostatic me ka hana antibacterial ikaika e kūʻē i nā ʻano bacteria Gram-positive a me Gram-negative. ʻO Hemolytic Pasteurella multocida, Pasteurella multocida, a me Actinobacillus pleuropneumoniae he mea maʻalahi loa ia i ka florfenicol. I loko o ka vitro, ua like a ʻoi aku ka ikaika o ka hana antibacterial a florfenicol e kūʻē i nā microorganism he nui ma mua o ka thiamphenicol. Hiki i kekahi mau hua bacteria kū'ē i ka amide-ʻona ma muli o ka acetylation, e like me Escherichia coli a me Klebsiella pneumoniae, hiki ke maʻalahi i ka florfenicol. Hoʻohana nui ʻia ia no nā maʻi bacterial i loko o nā puaʻa, nā moa, a me nā iʻa i hana ʻia e ka maʻi bacteria susceptible, e like me nā maʻi hanu i nā pipi a me nā puaʻa i hana ʻia e ka hemolytic Pasteurella multocida, Pasteurella multocida, a me Actinobacillus pleuropneumoniae. Hoʻohana ʻia ia no ka maʻi typhoid a me ka paratyphoid i hoʻokumu ʻia e Salmonella, kolera moa, ka maʻi pullorum, a me ka maʻi Escherichia coli; a me ka maʻi bacterial septicemia, enteritis, a me ka maʻi kiko ʻulaʻula i nā iʻa i hana ʻia e Pasteurella multocida, Vibrio, Staphylococcus aureus, Hydrophila, a me Enterobacteriaceae. Pharmacokinetics: Hoʻopili koke ʻia ʻo Florfenicol i ka waha, hiki i ka therapeutic concentrations i loko o ke koko ma kahi o 1 hola, a hiki ke kiʻekiʻe kiʻekiʻe o ka plasma i loko o 1-3 mau hola. ʻOi aku ka bioavailability ma mua o 80%. Hoʻolaha nui ʻia ʻo Florfenicol i loko o ke kino holoholona a hiki ke ʻaʻa i ke koko{17}}pale lolo. Hoʻokuʻu mua ʻia ʻo ia me ka loli ʻole i ka mimi, me kahi mea liʻiliʻi i hoʻokuʻu ʻia i loko o nā feces.
Pilikia laau
(1) Loaʻa i nā Macrolides a me nā lincosamides ka pahuhopu like me kēia huahana, ʻo ia ka hoʻopaʻa ʻana i ka subunit 50S o nā ribosomes bacteria. Ke hoʻohana pū ʻia, hiki iā lākou ke hana i nā hopena antagonistic.
(2) Hiki iā lākou ke kūʻē i ka hana bactericidal o penicillin a i ʻole aminoglycoside lāʻau, akā ʻaʻole i hōʻike ʻia kēia i nā holoholona.
Ka hoʻohana ʻana a me ka hoʻokele
Ma muli o kēia huahana. No ka hoʻohana i loko: 0.1-0.15g no ka kg kaumaha o ke kino no nā puaʻa a me nā moa, ʻelua i ka lā no 3-5 mau lā; 50-75mg no ka kg kaumaha o ke kino no ka iʻa, hoʻokahi manawa i ka lā no 3-5 mau lā.
Nā mea e mālama ai:
(1) ʻAʻole pono nā moa e hoʻomoe ana i nā hua no ka ʻai kanaka i kēia huahana i ka wā o kā lākou -wao hoʻohua hua.
(2) E hoʻohana me ka akahele i ka hānai ʻana i nā moa. Loaʻa iā ia ka embryotoxicity; hoʻohana me ka akahele i nā holoholona hāpai a me ka lactating.
(3) Hoʻopaʻa ʻia i nā holoholona i ka wā o ka hoʻopaʻa ʻana a i ʻole me ka hana pale kino.
(4) Pono nā holoholona me ka lawa ʻole o ka renal e hoʻemi kūpono ʻia a i ʻole e hoʻolōʻihi ʻia ka wā hoʻopaʻa.
Nā huahana pale: florfenicole pauda, Kina florfenicole pauda mea hana, hale hana
